Our laboratory is part of the Microbial Sciences Institute and the Department of Ecology and Evolutionary Biology at Yale University. Our work lies at the interface between systems biology and microbial community ecology and evolution. An important focus of the lab is understanding how the molecules microbes secrete to the environment, such as nutrients, toxins, etc., mediate the assembly and the evolution of microbial communities. 



10.15.2018: Our paper On the deformability of an empirical fitness landscape by microbial evolution is out today in PNAS! Congrats to Djordje, Jean and our much admired collaborator Zack Blount!

08.03.2018: Congrats to Josh, Nanxi, Djordje, Sylvie and Alicia! Our paper Emergent Simplicity in Microbial Community Assembly is out today in Science.

05.20.2018: Nanxi and Sylvie will be giving talks at the 2018 ISME meeting in Leipzig, Germany, on August 12-17

04.02.2018: Djordje and Jean's new preprint is in bioRxiv. In collaboration with Zack Blount (Michigan State), we have investigated the deformability of an empirical fitness landscape. 

03.15.2018: Nanxi and Alicia's new preprint is out! A fun collaboration with Mikhail Tikhonov at Stanford to investigate collective effects in microbial invasions and community coalescence. Congrats to all!

03.12.2018: Sylvie and Djordje have been selected to give talks at the 2018 ESEB-SSB-SSE-ASN Joint Evolution Meeting in Montpellier. Congratulations to both of them!



On the deformability of an empirical fitness landscape by microbial evolution.  Djordje Bajic*, Jean C.C. Vila*, Zachary D. Blount and Alvaro Sanchez (2018) PNAS 

Emergent simplicity in microbial community assembly. Joshua Goldford*, Nanxi Lu*, Djordje Bajic, Sylvie Estrela, Mikhail Tikhonov, Alicia Sanchez-Gorostiaga, Daniel Segre, Pankaj Mehta, and Alvaro Sanchez (2018) Science 

Cohesiveness in microbial community coalescence.  Nanxi Lu, Alicia Sanchez-Gorostiaga, Mikhail Tikhonov and Alvaro Sanchez (2018) BioRxiv

Cooperators trade off ecological resilience and evolutionary stability in public goods games
Joseph Rauch, Jane Kondev and Alvaro Sanchez (2017)  Journal of the Royal Society Interface 

Dynamics of a producer-freeloader ecosystem on the brink of collapse. Andrew Chen*, Alvaro Sanchez*, Lei Dai and Jeff Gore (2014)  Nature Communications 

Eco-evolutionary dynamics of complex social strategies in microbial communities Kyle Harrington and Alvaro Sanchez (2014) Communicative and Integrative Biology

Genetic determinants and cellular constraints in noisy gene expression Alvaro Sanchez and Ido Golding (2013)  Science 

Feedback between population and evolutionary dynamics determines the fate of social microbial populations Alvaro Sanchez and Jeff Gore (2013) PLOS Biology