ABOUT ALVARO (CV)

I am an Assistant Professor in the Ecology & Evolutionary Biology Department and the Microbial Sciences Institute at Yale. I did my Doctoral and Postdoctoral training at Brandeis and MIT, where I had the incredible opportunity to work with Jane Kondev and Jeff Gelles in bacterial gene regulation; and with Jeff Gore on eco-evolutionary and population dynamics of budding yeast. First as a Junior Fellow at Harvard and now as an Assistant Professor at Yale, I am applying systems biology tools such as dynamic Flux Balance Analysis models and high-throughput cultivation and phenotyping to study how microbial communities form, and how they evolve. I grew up in the beautiful medieval towns of Zamora and Salamanca, in the Northwestern Spanish region of Castilla y Leon -which I miss terribly. I have also lived and worked in Madrid, Geneva, the Twin Cities and, for the past fifteen years, in various towns and cities in New England.

SAMPLE OF REPRESENTATIVE PUBLICATIONS

  • High order interactions dominate the functional landscape of microbial consortia. Sanchez-Gorostiaga, A.*, Bajic, D.*, Osborne, M.L., Poyatos, J.F., Sanchez, A. BioRxiv (2018) 10.1101/333534, Under review at PLOS Biology

  • On the deformability of an empirical adaptive landscape by microbial evolution. Bajic, D.*, Vila, J.C.C.*, Blount, Z.D., Sanchez, A. PNAS (2018) 115(44):11286-11291

  • Emergent simplicity in microbial community assembly. Goldford, J.*, Lu, N.*, Bajic, D., Estrela, S., Sanchez-Gorostiaga, A., Tikhonov, M., Segre, D., Mehta, P., Sanchez, A. Science (2018) 361:469-74

  • Combinatorial gene regulation through kinetic control of the transcription cycle. Scholes, C., DePace A.H., Sanchez, A. Cell Systems (2017) 4: 97-108 

  • Dynamics of an experimental producer-freeloader ecosystem on the brink of collapse. Chen, A.*, Sanchez, A.*, Dai, L., Gore, J. Nature Communications (2014) 5 – 3713.

  • Genetic determinants and physical constraints in noisy gene expression. Sanchez, A.*, Golding, I.* Science (2013) 342:1188-1193.

  • Feedback between population and evolutionary dynamics determines the fate of social microbial populations. Sanchez, A., Gore, J. PLOS Biology (2013) 11(4): e1001547.

  • Regulation of noise in gene expression. Sanchez, A., Choubey, S., Kondev, J. Annual Review of Biophysics (2013) 42: 469–491.

  • Operator sequence alters gene expression independently of transcription factor occupancy in bacteria. Garcia H.G*., Sanchez, A.*, Boedicker, J.Q.*, Osborne, M.L., Gelles, J., Kondev, J., Phillips, R. Cell Reports (2012) 2: 150-161.

  • Transcriptional control of noise in gene expression. Sanchez, A., Kondev J. PNAS (2008) 105(13):5081-6.

TEACHING

At Yale I have taught:

  • EEB 225 - Evolutionary Biology ,

  • EEB 678 - Mathematical Models in Ecology & Evolution, and

  • EEB 729 - Microbial Ecology & Evolution.

In the summer of 2019 I will be a Lecturer at the Physical Biology of the Cell Summer Course at the Marine Biology Laboratory at Woods Hole, where I will lead a Theory rotation together with the two graduate students in the lab as TAs.

In the Fall of 2019 I will teach EEB 729 again. This year we will focus on the directed evolution of whole communities as a vehicle to learn about how microbial communities assemble and how they function. To that end, we will cover topics such as microbial community coalescence, priority effects, eco-evolutionary dynamics, microbial metabolic networks, etc. If you are a Yale student interested in taking part and want to know more, please contact Alvaro.