I am an Assistant Professor in the Department of Ecology & Evolutionary Biology and the Microbial Sciences Institute at Yale. I did my Doctoral and Postdoctoral training at Brandeis and MIT, where I had the fortune to work with Jane Kondev and Jeff Gelles in bacterial gene regulation, and with Jeff Gore on eco-evolutionary and population dynamics of budding yeast. Right before coming to Yale, I started an independent research lab at the Rowland Institute at Harvard. My professional CV can be found here. As a PI, I strive to create a highly collaborative environment where people have ownership and control over their projects and their time. I grew up in the beautiful Castilian towns of Zamora and Salamanca, in the northwest of Spain right by the border of Portugal (a little-known but extraordinarily beautiful -and very much worth a visit!- region of Europe). I have also lived and worked in Madrid, Geneva, the Twin Cities and, for the past fifteen years, in various towns and cities in New England.
SAMPLE REPRESENTATIVE PUBLICATIONS
High order interactions dominate the functional landscape of microbial consortia. Sanchez-Gorostiaga, A.*, Bajic, D.*, Osborne, M.L., Poyatos, J.F., Sanchez, A. BioRxiv (2018) 10.1101/333534, Under review at PLOS Biology
On the deformability of an empirical adaptive landscape by microbial evolution. Bajic, D.*, Vila, J.C.C.*, Blount, Z.D., Sanchez, A. PNAS (2018) 115(44):11286-11291
Emergent simplicity in microbial community assembly. Goldford, J.*, Lu, N.*, Bajic, D., Estrela, S., Sanchez-Gorostiaga, A., Tikhonov, M., Segre, D., Mehta, P., Sanchez, A. Science (2018) 361:469-74
Combinatorial gene regulation through kinetic control of the transcription cycle. Scholes, C., DePace A.H., Sanchez, A. Cell Systems (2017) 4: 97-108
Dynamics of an experimental producer-freeloader ecosystem on the brink of collapse. Chen, A.*, Sanchez, A.*, Dai, L., Gore, J. Nature Communications (2014) 5 – 3713.
Genetic determinants and physical constraints in noisy gene expression. Sanchez, A., Golding, I. Science (2013) 342:1188-1193.
Feedback between population and evolutionary dynamics determines the fate of social microbial populations. Sanchez, A., Gore, J. PLOS Biology (2013) 11(4): e1001547.
Regulation of noise in gene expression. Sanchez, A., Choubey, S., Kondev, J. Annual Review of Biophysics (2013) 42: 469–491.
Operator sequence alters gene expression independently of transcription factor occupancy in bacteria. Garcia H.G*., Sanchez, A.*, Boedicker, J.Q.*, Osborne, M.L., Gelles, J., Kondev, J., Phillips, R. Cell Reports (2012) 2: 150-161.
Transcriptional control of noise in gene expression. Sanchez, A., Kondev J. PNAS (2008) 105(13):5081-6.
At Yale I have taught:
EEB 225 - Evolutionary Biology,
EEB 678 - Mathematical Models in Ecology & Evolution, and
EEB 729 - Microbial Ecology & Evolution.
In the summer of 2019 I will be a Lecturer at the Physical Biology of the Cell Summer Course at the Marine Biology Laboratory at Woods Hole, where I will lead a Theory rotation together with the two graduate students in the lab as TAs.
In the Fall of 2019 I will teach EEB 729 again. This year we will focus on the directed evolution of whole communities as a vehicle to learn about how microbial communities assemble and how they function. To that end, we will cover topics such as microbial community coalescence, priority effects, eco-evolutionary dynamics, microbial metabolic networks, etc. If you are a Yale student interested in taking part and want to know more, please feel free to contact me.
UPCOMING SEMINARS AND TALKS
August 19-24 2019: Marine Biology Laboratory at Woods Hole. Physical Biology of the Cell Summer Course
September 19 2019: UC Berkeley, Department of Integrative Biology Seminar Series
September 25 2019: University of British Columbia, Department of Zoology Seminar Series
November 1 2019: The Jackson Laboratory. Meeting on experimental approaches to characterizing diverse microbiomes
February 20, 2020: Georgia Tech. Department of Biology Seminar Series
POPULAR PRESS AND MEDIA
Alvaro is interviewed about microbial cooperation (radio in Spanish)