ABOUT ALVARO (CV)
I am an Assistant Professor in the Ecology & Evolutionary Biology Department and the Microbial Sciences Institute at Yale. I did my Doctoral and Postdoctoral training at Brandeis and MIT, where I had the incredible opportunity to work with Jane Kondev and Jeff Gelles in bacterial gene regulation; and with Jeff Gore on eco-evolutionary and population dynamics of budding yeast. First as a Junior Fellow at Harvard and now as an Assistant Professor at Yale, I am applying systems biology tools such as dynamic Flux Balance Analysis models and high-throughput cultivation and phenotyping to study how microbial communities form, and how they evolve. I grew up in the beautiful medieval towns of Zamora and Salamanca, in the Northwestern Spanish region of Castilla y Leon -which I miss terribly. I have also lived and worked in Madrid, Geneva, the Twin Cities and, for the past fifteen years, in various towns and cities in New England.
SAMPLE OF REPRESENTATIVE PUBLICATIONS
High order interactions dominate the functional landscape of microbial consortia. Sanchez-Gorostiaga, A.*, Bajic, D.*, Osborne, M.L., Poyatos, J.F., Sanchez, A. BioRxiv (2018) 10.1101/333534, Under review at PLOS Biology
On the deformability of an empirical adaptive landscape by microbial evolution. Bajic, D.*, Vila, J.C.C.*, Blount, Z.D., Sanchez, A. PNAS (2018) 115(44):11286-11291
Emergent simplicity in microbial community assembly. Goldford, J.*, Lu, N.*, Bajic, D., Estrela, S., Sanchez-Gorostiaga, A., Tikhonov, M., Segre, D., Mehta, P., Sanchez, A. Science (2018) 361:469-74
Combinatorial gene regulation through kinetic control of the transcription cycle. Scholes, C., DePace A.H., Sanchez, A. Cell Systems (2017) 4: 97-108
Dynamics of an experimental producer-freeloader ecosystem on the brink of collapse. Chen, A.*, Sanchez, A.*, Dai, L., Gore, J. Nature Communications (2014) 5 – 3713.
Genetic determinants and physical constraints in noisy gene expression. Sanchez, A.*, Golding, I.* Science (2013) 342:1188-1193.
Feedback between population and evolutionary dynamics determines the fate of social microbial populations. Sanchez, A., Gore, J. PLOS Biology (2013) 11(4): e1001547.
Regulation of noise in gene expression. Sanchez, A., Choubey, S., Kondev, J. Annual Review of Biophysics (2013) 42: 469–491.
Operator sequence alters gene expression independently of transcription factor occupancy in bacteria. Garcia H.G*., Sanchez, A.*, Boedicker, J.Q.*, Osborne, M.L., Gelles, J., Kondev, J., Phillips, R. Cell Reports (2012) 2: 150-161.
Transcriptional control of noise in gene expression. Sanchez, A., Kondev J. PNAS (2008) 105(13):5081-6.
At Yale I have taught:
EEB 225 - Evolutionary Biology ,
EEB 678 - Mathematical Models in Ecology & Evolution, and
EEB 729 - Microbial Ecology & Evolution.
In the summer of 2019 I will be a Lecturer at the Physical Biology of the Cell Summer Course at the Marine Biology Laboratory at Woods Hole, where I will lead a Theory rotation together with the two graduate students in the lab as TAs.
In the Fall of 2019 I will teach EEB 729 again. This year we will focus on the directed evolution of whole communities as a vehicle to learn about how microbial communities assemble and how they function. To that end, we will cover topics such as microbial community coalescence, priority effects, eco-evolutionary dynamics, microbial metabolic networks, etc. If you are a Yale student interested in taking part and want to know more, please contact Alvaro.