Our laboratory is part of the Microbial Sciences Institute and the Department of Ecology and Evolutionary Biology at Yale University. Our work lies at the interface between systems biology and microbial community ecology and evolution. An important focus of the lab is understanding how the molecules microbes secrete to the environment, such as nutrients, toxins, etc., mediate the assembly and the evolution of microbial communities. 



05.20.2018: Nanxi and Sylvie will be giving talks at the 2018 ISME meeting in Leipzig, Germany, on August 12-17

04.02.2018: Djordje and Jean's new preprint is in bioRxiv. In collaboration with Zack Blount (Michigan State), we have investigated the deformability of an empirical fitness landscape. 

03.15.2018: Nanxi and Alicia's new preprint is out! A fun collaboration with Mikhail Tikhonov at Stanford to investigate collective effects in microbial invasions and community coalescence. Congrats to all!

03.12.2018: Sylvie and Djordje have been selected to give talks at the 2018 ESEB-SSB-SSE-ASN Joint Evolution Meeting in Montpellier. Congratulations to both of them!

10.19.2017: Our laboratory's first preprint is out! A wonderful piece of work by visiting student Joshua Goldford, in collaboration with the entire postdoc cohort that started the lab together: Nanxi, Djordje, Sylvie and Alicia. Congratulations to all of them!

07.01.2016: Our lab has relocated to Yale University’s West Campus, where Alvaro has accepted a position as Assistant Professor in the Department of Ecology & Evolutionary Biology.

07.01.2016: Alvaro was awarded a Young Investigator Grant from the Human Frontier Science Program. We will collaborate with two other groups developing models of host-associated microbial population dynamics.

07.01.2016: Our lab got a Scialog seed grant from the Simons Foundation to understand microbial diversity in complex laboratory ecosystems. We will be working in collaboration with Pankaj Mehta (BU) in this exciting project.



On the deformability of an empirical fitness landscape by microbial evolution
Djordje Bajic*, Jean C.C. Vila*, Zachary D. Blount and Alvaro Sanchez
BioRxiv (2018) doi: 10.1101/293407

Cohesiveness in microbial community coalescence. 
Nanxi Lu, Alicia Sanchez-Gorostiaga, Mikhail Tikhonov and Alvaro Sanchez
BioRxiv (2018) doi: 10.1101/282723

Emergent simplicity in microbial community assembly. 
Joshua Goldford*, Nanxi Lu*, Djordje Bajic, Sylvie Estrela, Mikhail Tikhonov, Alicia Sanchez-Gorostiaga, Daniel Segre, Pankaj Mehta, and Alvaro Sanchez
BioRxiv (2017) 

Cooperators trade off ecological resilience and evolutionary stability in public goods games
Joseph Rauch, Jane Kondev and Alvaro Sanchez
Journal of the Royal Society Interface (2017) 

Dynamics of a producer-freeloader ecosystem on the brink of collapse
Andrew Chen*, Alvaro Sanchez*, Lei Dai and Jeff Gore
Nature Communications (2014) 

Eco-evolutionary dynamics of complex social strategies in microbial communities
Kyle Harrington and Alvaro Sanchez
Communicative and Integrative Biology (2014) 

Genetic determinants and cellular constraints in noisy gene expression
Alvaro Sanchez and Ido Golding
Science (2013) 

Feedback between population and evolutionary dynamics determines the fate of social microbial populations
Alvaro Sanchez and Jeff Gore
PLOS Biology (2013) 



Alvaro will give a seminar at the Widely Applied Mathematics Seminar Series at Harvard School of Engineering and Applied Sciences on November 30, 2017

Alvaro will give a seminar at the University of Cologne Evolution Colloquium on March 7 2018

Alvaro will speak at the Stochastic Models in Ecology & Evolutionary Biology Workshop in Venice, Italy in April 5-7 2018

Jean and Djordje will present at the Evolutionary Systems Biology Conference organized at the Wellcome Genome Campus in Cambridge, UK

Alvaro will give a seminar at the University of Minnesota BioTechnology Institute on May 5 2018

Alvaro is Co-organizing an ASPEN Summer Conference on the Physical Principles Governing the Organization of Microbial Communities at the ASPEN Center for Physics, June 3-24 2018

Sylvie and Djordje have been both selected to give talks at the 2018 ESEB-SSB-SSE-ASN joint evolution meeting in Montpellier. Jean will be presenting a poster at the meeting too.

Sylvie and Nanxi will give talks at ISME meeting in Leipzing, August 12-17 2018